Endocrine Abstracts

Aim: Radioactive iodine (RAI) ablation therapy is used as part of the treatment for hyperthyroidism. Recently, low dose applied 131I treatment for hyperthyroidism has decreased the need for thyroidectomy. The aim of this study was to evaluate serum fasting glucose (FG) values in pre and post treatment RAI patients.Materials and Methods: Thirty-two patients with hyperthyroidism (mean age 56.0±14.5 years; range 24–83) treated with a si...

Introduction and objective: Recently, a lot of studies associated with high mean platelet level (MPV) in patients with hypo- and hyperthyroidism has reported in medical litherature. But it is not clear whether or not radioactive iodine treatment effect on platelet activity. It is well known that elevated platelet size is associated with its high enzymatic and metabolic activity. Aim of our preliminary study is to determine the platelet size via MPV level in hyperthyroid patien...

Introduction: Hypopituitarism is defined as either partial or complete deficiency of anterior or posterior pituitary hormone secretion or both. Hypopituitarism itself may increase the risk of thromboembolism/hypercoagulopathy, and underlying mechanisms of hemostatic dysfunctions in hypopituitarism are mostly unknown. Reduced enzymatic activity due to methylenetetrahydrofolate reductase (MTHFR) gene mutations are associated with hyperhomocysteinemia and have been linked to both...

Background: MEN-1 is a rare disease characterized by parathyroid adenoma or hyperplasia, pituitary adenoma and pancreatic neuroendocrine tumors (PNET). Gastrinomas are the most common functional PNET in MEN-1 disease. Insulinomas and glucagonomas constitute approximately 20 and 3% of PNET’s in MEN-1 disease. Most of insulinomas are benign in nature but about 70% of cases of glucagonomas present with metastasis at diagnosis. Coexistence of various PNET’s are very rare...

Introduction: Insulin resistance is the decrease sensitivity of tissues in the body to insulin effect. Obesity, advanced age, sedentary life and smoking are the factors leading to an increase in insulin resistance. In our study, we aimed to evaluate the relationship between the insulin resistance and smoking in individuals without advanced age, obesity, high blood glucose levels and hypertension.Materials and methods: We included in this study 100 patien...

Introduction: Hypoglycemia is the most common endocrinological problem in emergency departments.Objective: To explore the causes of hypoglycemia in patients who were admitted to the emergency department with symptoms resembling hypoglycemia.Design: In our study, 225 hypoglycemia cases were evaluated from January 2000 to May 2008.Results: Of 225 hypoglycemia cases, 158 (70.2%) receiving treatment for diabetes ...

Introduction: Recent conducted studies show that clinical hypothyroidism (CH) has similar cardiovascular risk with subclinical hypothyroidism (SCH). Carotid intima media thickness (CIMT) that is an important marker of early atherosclerotic changes is an indicator of cardiovascular events. In our study, we evaluated CIMT in female patients, who have both CH and SCH, with similar age and demographic features.Materials and methods: We recruited 38 healthy f...

Background: Diabetic foot ulcer and lower extremity amputation are leading causes of mortality and morbidity in diabetic patients. Diabetic neuropathy and peripheral vascular disease are major reasons for diabetic foot ulcer. Most of the studies showed that hyperhomocystinemia is related with microvascular and macrovascular complications in diabetic patients. Also hyperhomocysteinemia is related to poor ulcer healing. In this study, we investigated the relationship of hyperhom...

Objective: Acromegaly is associated with increased morbidity and mortality, mostly due to cardiovascular complications. Thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with coagulation/fibrinolysis and inflammation. Plasma TAFI may participate in arterial thrombosis in cardiovascular diseases (CVD). In this study, we aimed to evaluate the levels of TAFI antigen and also its relationship with other markers in a group of patients with acromegaly in compoa...

Acromegaly is known to be associated with both increased cardiovascular mortality and carbohydrate intolerance. The aim of our study is to compare intima-media thickness, a marker of atherosclerosis in active acromegalic patients with and without diabetes. 32 active acromegalic patients (M/ F: 15/17, 16 diabetic and 16 nondiabetic) were assessed for fasting blood glucose (FBG), insulin, growth hormone, insulin-like growth factor 1 and carotid intima-media thickness (IMT). Diab...